The 2025 Nobel Prize in Medicine has been awarded jointly to American scientists Mary Brunkow and Fred Ramsdell, and Japan’s Shimon Sakaguchi for groundbreaking research revealing how the immune system distinguishes and protects healthy cells — a discovery paving the way for new treatments for autoimmune diseases and cancer.The Nobel Assembly at Sweden’s Karolinska Institute announced the laureates on Monday, recognising their pioneering work on peripheral immune tolerance — the body’s ability to control immune responses to prevent self-damage while defending against infections.Their discoveries have laid the foundation for a new field of research and spurred the development of novel therapies, including those targeting cancer and autoimmune disorders,” the Nobel committee said in its citation.The three scientists were honoured for identifying regulatory T cells — specialised immune cells that act as the body’s security system, preventing the immune response from attacking its own tissues.Sakaguchi, a professor at Osaka University, told ...